Yes, it is possible to use multiple midi controllers to play multiple instruments in Reason. However, only one of them gets to be the master keyboard at a time.
This only matters when you need to record a performance. Reason will only record midi from the master keyboard. Also, the master keyboard can be assigned to different instruments easily by just clicking on the device's track in the sequencer.
The other keyboards are assigned to specific instruments through the midi devices section of Reason's hardware interface device at the top of the rack.
Want to use multiple hardware control surfaces at the same time in Propellerhead Reason?
In this video, I'm using multiple USB/MIDI hardware controllers (Akai MPD32 and M-Audio Oxygen25) at the same time. I show how you can setup and use each control surface to trigger a specific device within Propellerhead Reason.
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Grace and Peace!
Taurus M. James
Music: "Hood Butterflies"
(Copyright 2011 by Taurus M. James - ASCAP)